DA-DRD5 signaling reprograms B cells to promote CD8+ T cell-mediated antitumor immunity

Neuronal signals have emerged as pivotal regulators of B cells that regulate antitumor immunity and tumor progression. However, the functional relevance and mechanistic basis of the effects of the neurotransmitter dopamine (DA) on tumor immunity remain elusive. Here, we discovered that plasma DA levels are positively correlated with circulating B cell numbers and potently activate B cell responses in a manner dependent on the DRD5 receptor. Notably, DRD5 signaling enhanced the Janus kinase 1 (JAK1)-STAT1 signaling in B cell responses, which enhanced B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion and cytotoxicity in tumor-specific effector of T cells. Our findings demonstrate that DA signaling suppresses tumor progression and highlight DRD5 as a promising target for cancer immunotherapy.

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Publication Details

Journal
Cell Reports
Published
2025-03-01
DOI
https://doi.org/10.1016/j.celrep.2025.115364
Citations
2
Primary Topic
Immune Cell Function and Interaction
Type
article
Field-Weighted Citation Impact
1.59
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article

DA-DRD5 signaling reprograms B cells to promote CD8+ T cell-mediated antitumor immunity

Ying bao Wang, Chunmei Ma, Yuqing Wu, Shiyang Pan et al.
2 citations
Cell Reports
Immune Cell Function and Interaction
1.59
article

DA-DRD5 signaling reprograms B cells to promote CD8+ T cell-mediated antitumor immunity

Ying bao Wang, Chunmei Ma, Yuqing Wu, Shiyang Pan, Yingchao Hu, Yuying Jiang, Yongbing Yang, Min Gao, Pei-Wen Xi, Sheng Li, Lu Liu, Lei Zhu, Mu Yuan, Qiaoying Zhu, Chunyan Wu, Lijun Liang, Qiang Ding
article en
2 citations

Abstract

Neuronal signals have emerged as pivotal regulators of B cells that regulate antitumor immunity and tumor progression. However, the functional relevance and mechanistic basis of the effects of the neurotransmitter dopamine (DA) on tumor immunity remain elusive. Here, we discovered that plasma DA levels are positively correlated with circulating B cell numbers and potently activate B cell responses in a manner dependent on the DRD5 receptor. Notably, DRD5 signaling enhanced the Janus kinase 1 (JAK1)-STAT1 signaling in B cell responses, which enhanced B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion and cytotoxicity in tumor-specific effector of T cells. Our findings demonstrate that DA signaling suppresses tumor progression and highlight DRD5 as a promising target for cancer immunotherapy.

Cell ReportsVol. 44(3)
Jiangnan University (CN), Shanghai Jiao Tong University (CN), Nanjing Maternity and Child Health Care Hospital (CN), Tongren Hospital (CN), Shanghai East Hospital (CN), National Center for Clinical Laboratories (CN), Jiangsu Province Hospital (CN), Second Affiliated Hospital of Zhejiang University (CN), Nanjing Medical University (CN)
Zero hunger
Openalex Percentile: Top 19%
Immune Cell Function and Interaction
1.59
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