Acute dentate nucleus deep brain stimulation modulates corticomotor excitability in chronic stroke survivors
Acute DN-DBS leads to heightened ipsilesional corticomotor excitability in moderate-to-severe chronic stroke survivors. Effects of acute DN-DBS on physiology are contingent upon structural preservation of key white matter tracts and associated with motor gains made with chronic DN-DBS. Findings provide mechanistic support of DN-DBS as a potential therapy for post-stroke motor recovery and potential of TMS to monitor responses.
Authors
- Ela B. Plow (ORCID: https://orcid.org/0000-0001-7788-7760)
- Yin‐Liang Lin (ORCID: https://orcid.org/0000-0002-4404-6129)
- Kyle O’Laughlin
- Xin Li (ORCID: https://orcid.org/0000-0002-4664-0244)
- Kenneth B. Baker (ORCID: https://orcid.org/0000-0002-4435-7015)
- André G. Machado (ORCID: https://orcid.org/0000-0002-8132-5610)
- Robert Chen (ORCID: https://orcid.org/0000-0002-8371-8629)
- Jacqueline Chen (ORCID: https://orcid.org/0000-0002-9896-6262)
- Kelsey Baker (ORCID: https://orcid.org/0009-0008-7506-4072)
Institutions
- Cleveland Clinic (US)
- University Health Network (CA)
- National Yang Ming Chiao Tung University (TW)
- University of Toronto (CA)
- Toronto Rehabilitation Institute (CA)
- The University of Texas Rio Grande Valley (US)
- Cleveland Clinic Lerner College of Medicine (US)
- The Neurological Institute (US)
- Krembil Research Institute
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.brs.2025.02.021
- Citations
- 1
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- American Heart Association
- Biogen
- Cleveland Clinic
- Novo Nordisk
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke