High-dimensional deconstruction of HNSC reveals clinically distinct cellular states and ecosystems that are associated with prognosis and therapy response
Our large-scale integrative transcriptome analysis provides high-resolution insights into the cellular states and ecosystems of HNSC, facilitating the discovery of novel biomarkers and supporting the development of precision therapies.
Authors
- Zhe Shen (ORCID: https://orcid.org/0000-0003-0639-4509)
- Zhaoyu Pan
- Chao Liu (ORCID: https://orcid.org/0000-0003-2184-9102)
- Yuanzheng Qiu (ORCID: https://orcid.org/0000-0001-9518-388X)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-9273-6212)
- Yong Liu (ORCID: https://orcid.org/0009-0000-7984-7463)
- Lei Xiao (ORCID: https://orcid.org/0000-0003-0246-2762)
- Donghai Huang (ORCID: https://orcid.org/0000-0002-8905-3234)
Institutions
- Central South University (CN)
- Hunan University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s12967-025-06299-4
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China