A multi-omics target study for glioblastoma multiforme (GBM) based on Mendelian randomization analysis
In summary, the plasma protein RPN1 and the CSF proteins vWF and MSP are causally associated with the risk of GBM. Further research is needed to clarify the roles of these candidate proteins in GBM. Notably, RPN1 may serve as a potential therapeutic target for GBM. Future clinical studies on GBM treatment could explore drugs targeting RPN1.
Authors
- Xiangyin Liu
- D. Lu
- Xianyong Yin (ORCID: https://orcid.org/0000-0001-6454-2384)
- Tao Xin (ORCID: https://orcid.org/0000-0002-8797-3002)
- Hao Fan (ORCID: https://orcid.org/0000-0002-0822-1639)
- Shan Wang (ORCID: https://orcid.org/0000-0002-0273-8397)
- Jun Lu
- Yuming Li (ORCID: https://orcid.org/0000-0002-8299-0495)
- Hao Sun (ORCID: https://orcid.org/0000-0003-0556-8212)
- Yuwen Song (ORCID: https://orcid.org/0000-0002-7336-6455)
- Zi-jian Zhou (ORCID: https://orcid.org/0000-0002-2051-5744)
- Haohan Sun
Institutions
- Weifang Medical University (CN)
- Precision for Medicine (United States) (US)
- Shandong Provincial Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Shandong First Medical University (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.ibneur.2025.02.011
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Taishan Scholar Foundation of Shandong Province
- Taishan Scholar Project of Shandong Province
- Shandong First Medical University