Generation of phenotypically stable and functionally mature human bone marrow MSCs derived Schwann cells via the induction of human iPSCs-derived sensory neurons
These results demonstrated that phenotypically stable and functionally mature hBMSC-dSCs were generated efficiently via the co-culture of hiPSC-dSNs and hBMSC-derived SCLCs. Our findings may provide a promising protocol through which stable and fully developed hBMSC-dSCs can be used for transplantation to regenerate myelin sheath.
Authors
- Sa Cai (ORCID: https://orcid.org/0000-0002-1370-0028)
- Manhon Chung (ORCID: https://orcid.org/0000-0003-0984-3461)
- Haohui Lin
- Li Zhang (ORCID: https://orcid.org/0000-0003-3330-0934)
- Yi Yang (ORCID: https://orcid.org/0000-0001-8394-9390)
- Xiaohua Pan
Institutions
- Shenzhen University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s13287-025-04217-5
- Citations
- 2
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province