Wnt1 oversees microglial activation by the Wnt/LRP5/6 receptor signaling pathway during lipopolysaccharide-mediated toxicity
The anti-inflammatory effects of Wnt1 on BV2 cells improved autophagy, a mechanism partly dependent on the β-catenin pathway or the phosphorylation of LKB1. Furthermore, the Wnt1/LKB1 pathway was activated independently of β-catenin and participated in regulating its expression. Our research unveils a previously unknown method through which Wnt1 exerts its anti-inflammatory effects, which may have a potential protective role against CNS diseases.
Authors
- Jinzhi Gao (ORCID: https://orcid.org/0000-0002-1183-4671)
- Xuan Sun (ORCID: https://orcid.org/0000-0001-8692-9838)
- Hao Xu (ORCID: https://orcid.org/0000-0001-6459-1063)
- Qingsong Wang (ORCID: https://orcid.org/0000-0002-6686-195X)
- Zhihui Rong (ORCID: https://orcid.org/0000-0002-2115-619X)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1007/s11033-025-10360-2
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China