Unsupervised subtyping of motor dysfunction of Parkinson's disease and its structural brain imaging correlates
Three PD subtypes of motor dysfunction were identified. Structural brain imaging revealed subtype-specific differences not only in cingulum and putamen regions, but also in the olfactory cortex, parahippocampal gyrus, and cerebellum, correlating with motor symptoms. Non-motor features varied by subtype, with increasing severity from tremor-dominant to akinetic-rigid.
Authors
- Jong‐Ling Fuh (ORCID: https://orcid.org/0000-0001-9135-3351)
- Yuangxiang Lin
- A.-H. Yang (ORCID: https://orcid.org/0009-0005-9312-7899)
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
Publication Details
- Journal
- Neuroimage Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.ynirp.2025.100246
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39