Wide Margins are Still Relevant: A Case of a Well-Circumscribed Borderline Phyllodes Tumor With a Satellite Nodule in a Re-excision Margin

Phyllodes tumors (PTs) of the breast are rare fibroepithelial neoplasms with high rates of local recurrence (LR) for which surgical excision remains the mainstay of treatment. The recommended surgical margin width is debated and varies based on the histologic grade. We present a case of a middle-aged woman with a well-circumscribed borderline PT who underwent margin re-excision, with a distinct focus of the PT detected at a previously negative margin. Given the high rates of LR and potential for histologic upgrade at the time of recurrence, combined with the current limited understanding of peritumoral tissue and possible satellite foci, a wide negative margin remains the recommendation for borderline PTs.

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Journal
Cureus
Published
2025-03-01
DOI
https://doi.org/10.7759/cureus.79890
Primary Topic
Breast Lesions and Carcinomas
Type
article
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article

Wide Margins are Still Relevant: A Case of a Well-Circumscribed Borderline Phyllodes Tumor With a Satellite Nodule in a Re-excision Margin

Rachel E. Factor, Rex C. Bentley, William R. Jeck, Gina Sotolongo et al.
1 links
Cureus
Breast Lesions and Carcinomas
article

Wide Margins are Still Relevant: A Case of a Well-Circumscribed Borderline Phyllodes Tumor With a Satellite Nodule in a Re-excision Margin

Rachel E. Factor, Rex C. Bentley, William R. Jeck, Gina Sotolongo, Laura Horst Rosenberger, Ellery H Reason
article en

Abstract

Phyllodes tumors (PTs) of the breast are rare fibroepithelial neoplasms with high rates of local recurrence (LR) for which surgical excision remains the mainstay of treatment. The recommended surgical margin width is debated and varies based on the histologic grade. We present a case of a middle-aged woman with a well-circumscribed borderline PT who underwent margin re-excision, with a distinct focus of the PT detected at a previously negative margin. Given the high rates of LR and potential for histologic upgrade at the time of recurrence, combined with the current limited understanding of peritumoral tissue and possible satellite foci, a wide negative margin remains the recommendation for borderline PTs.

CureusVol. 17(3)
Duke University (US), Duke University Health System (US)
Openalex Percentile: Top 95%
Breast Lesions and Carcinomas
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Wide Margins are Still Relevant: A Case of a Well-Circumscribed Borderline Phyllodes Tumor With a Satellite Nodule in a Re-excision Margin — Rachel E. Factor, Rex C. Bentley, et al. · Cureus (2025) | TGRS Research Map | TGRS