The role of oxidative stress-mediated fibro-adipogenic progenitor senescence in skeletal muscle regeneration and repair
In this study, we first found FAPs underwent senescence and redox homeostasis imbalance after injury. Next, we utilized melatonin to enhance FAPs regenerative and repair capabilities by activating AMPK signaling pathway. Taken together, this work provides a novel theoretical foundation for treating skeletal muscle injury.
Authors
- Jiancheng Wang (ORCID: https://orcid.org/0000-0001-9599-0171)
- Yannan Wang (ORCID: https://orcid.org/0000-0001-7634-9485)
- Zeyu Xu (ORCID: https://orcid.org/0009-0001-3685-9744)
- Yusheng Luo
- Xiaomei Liang (ORCID: https://orcid.org/0000-0001-5335-0213)
- Xin Li (ORCID: https://orcid.org/0000-0002-4842-5054)
- Miao Zhang (ORCID: https://orcid.org/0000-0003-4912-2570)
- Chao Song (ORCID: https://orcid.org/0000-0002-8200-7673)
- Yuqing Yao (ORCID: https://orcid.org/0000-0002-8497-1749)
- Zhigang Hong (ORCID: https://orcid.org/0000-0001-7012-1770)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s13287-025-04242-4
- Citations
- 8
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province