X-chromosome-linked miR-542-5p as a key regulator of sex disparity in rats with adjuvant-induced arthritis by promoting Th17 differentiation
This study offers new insights into the sex-specific nature of RA, suggesting X-linked miR-542-5p as a potential target for both diagnostic and therapeutic purposes. These findings lay the groundwork for the development of gender-specific therapeutic strategies for RA and underscore the importance of gender consideration in RA research.
Authors
- Hui Miao Wang
- Vincent Kam Wai Wong (ORCID: https://orcid.org/0000-0002-2951-8108)
- Jerome P. L. Ng (ORCID: https://orcid.org/0000-0001-9282-0353)
- Kyungho Ha (ORCID: https://orcid.org/0000-0002-0397-2070)
- Kah Fai Leong (ORCID: https://orcid.org/0000-0002-9302-1163)
- Ding Qi Zhang
- Jie Yang (ORCID: https://orcid.org/0000-0003-2241-5066)
- Chuzhao Lei (ORCID: https://orcid.org/0000-0003-1647-1037)
- Michelle Liu (ORCID: https://orcid.org/0000-0002-4155-2931)
- Baochun Huang (ORCID: https://orcid.org/0000-0002-9442-5661)
- Joyce Tsz Wai Chan
- Pou M (ORCID: https://orcid.org/0000-0001-5826-6045)
- David Wei Zhang (ORCID: https://orcid.org/0000-0002-8675-5273)
- Wei Luo
- Xiaowei Xu (ORCID: https://orcid.org/0000-0001-8790-2450)
- Lin Na Wang
- Betty Yuen Kwan Law (ORCID: https://orcid.org/0000-0002-8926-3960)
- Lek Hang Cheang
- Peter Y. K. Cheung (ORCID: https://orcid.org/0000-0002-8236-1816)
- Zhi Li (ORCID: https://orcid.org/0000-0002-6793-9560)
- Yi Li (ORCID: https://orcid.org/0000-0002-3875-3513)
- Yipeng Wang (ORCID: https://orcid.org/0000-0001-9769-9839)
- Bo Qin (ORCID: https://orcid.org/0000-0002-4283-4041)
- Chang Liu (ORCID: https://orcid.org/0000-0003-2517-9425)
- C. H. Leong
- Wan Yu Wu
- Xiang Yun
- Wang Fai Ao Ieong
Institutions
- Macau University of Science and Technology (MO)
- Hospital Conde S. Januário (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s40364-025-00741-x
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Fundo para o Desenvolvimento das Ciências e da Tecnologia