Handling missing values in patient-reported outcome data in the presence of intercurrent events
Information about the timing and occurrence of ICEs contribute to a more plausible handling of missing PRO data. To account for ICE information when handling missing PROs, the missing data model should be separated from the analysis model.
Authors
- Ragnhild Sørum Falk (ORCID: https://orcid.org/0000-0001-8398-3492)
- Tove Ragna Reksten (ORCID: https://orcid.org/0000-0001-8704-4943)
- Willi Sauerbrei (ORCID: https://orcid.org/0000-0002-6792-4123)
- Ahu Alanya (ORCID: https://orcid.org/0009-0007-0627-4300)
- Jennifer A. Black (ORCID: https://orcid.org/0000-0001-7049-3814)
- Doranne Thomassen (ORCID: https://orcid.org/0000-0002-9450-6015)
- Jaap C. Reijneveld (ORCID: https://orcid.org/0000-0002-2257-3147)
- Satrajit Roychoudhury (ORCID: https://orcid.org/0000-0003-4001-3036)
- Gerhard Rumpold (ORCID: https://orcid.org/0000-0002-6037-793X)
- Jammbe Musoro (ORCID: https://orcid.org/0000-0002-6228-3531)
- Rajesh Kamalakar
- Samantha Cruz Rivera (ORCID: https://orcid.org/0000-0002-1566-6804)
- Geert Molenberghs (ORCID: https://orcid.org/0000-0002-6453-5448)
- Kavita Sail
- Antoine Regnault (ORCID: https://orcid.org/0000-0001-8234-2896)
- Anja Schiel (ORCID: https://orcid.org/0000-0002-1258-4731)
- Christoph Gerlinger (ORCID: https://orcid.org/0000-0003-4538-6413)
- Paul G. Kluetz (ORCID: https://orcid.org/0000-0002-9796-4791)
- Khadija Rantell (ORCID: https://orcid.org/0000-0002-6747-7650)
- Cecilie Delphin Amdal (ORCID: https://orcid.org/0000-0001-8422-8085)
- Kelly Van Lancker (ORCID: https://orcid.org/0000-0003-3458-3788)
- Melanie Calvert (ORCID: https://orcid.org/0000-0002-1856-837X)
- Claudia Rutherford (ORCID: https://orcid.org/0000-0002-4637-4572)
- Vishal Bhatnagar (ORCID: https://orcid.org/0000-0003-4650-0513)
- Saskia le Cessie (ORCID: https://orcid.org/0000-0003-2154-4923)
- Dries Reynders (ORCID: https://orcid.org/0000-0001-6875-048X)
- Mallorie H. Fiero (ORCID: https://orcid.org/0000-0001-5536-116X)
- Silene ten Seldam
- Olalekan Lee Aiyegbusi (ORCID: https://orcid.org/0000-0001-9122-8251)
- Ethan Basch (ORCID: https://orcid.org/0000-0003-3813-9318)
- Els Goetghebeur (ORCID: https://orcid.org/0000-0002-8896-0721)
- Joseph C. Cappelleri (ORCID: https://orcid.org/0000-0001-9586-0748)
- Limin Liu
- Ting‐Yu Chen (ORCID: https://orcid.org/0000-0002-3445-9907)
- Alicyn Campbell
- David Ness
- Michael Schlichting
- Alexander Russell-Smith
- Maxime Sasseville
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- Oslo University Hospital (NO)
- University of Freiburg (DE)
- Pfizer (United States) (US)
- Leiden University Medical Center (NL)
- Ghent University (BE)
- European Organisation for Research and Treatment of Cancer (BE)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s12874-025-02510-8
- Citations
- 6
- Primary Topic
- Statistical Methods and Inference
- Type
- article
- Field-Weighted Citation Impact
- 15.78
Funders
- American Society of Clinical Oncology
- Health Canada
- National Cancer Institute