The role of adipose tissue in colorectal cancer

Abstract In this review we discuss the role of adipose tissue in colorectal cancer (CRC). CRC is one of the deadliest cancers worldwide and, in fact, the third most common. However, it can be mainly prevented by an adequate diet. We explored and studied articles in-depth in order to develop better understanding about CRC. We highlight, that markers such as TNF-α, IL-6 and IL-8/CXCL8 are the major players responsible for causing CRC. In addition, fat-induced insulin resistance also contributes to the risk of CRC. We emphasize that the best way to prevent colorectal cancer is to consume a fiber-rich diet and do physical activity on a regular basis. We aim to explore the importance of adipose tissue as an endocrine organ, how it relates to obesity as well as the crucial role adipose tissue play in progression of colon cancer.