The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers
This study establishes clinically accessible imaging biomarkers that capture the molecular composition and oncogenic drivers of glioblastoma. These findings have potential implications for noninvasive tumor profiling, personalized therapies, and improved patient stratification in clinical trials.
Authors
- Xiaoju Hu (ORCID: https://orcid.org/0000-0001-6308-7172)
- Anahita Fathi Kazerooni (ORCID: https://orcid.org/0000-0001-7131-2261)
- Ashish Singh (ORCID: https://orcid.org/0000-0003-4486-3636)
- Stephen Bagley (ORCID: https://orcid.org/0000-0002-7117-0539)
- Erik Toorens
- Dimitris Grigoriadis (ORCID: https://orcid.org/0000-0002-2386-5272)
- Robyn T. Sussman (ORCID: https://orcid.org/0000-0002-4057-9622)
- Nadia Dahmane
- Dominique Ballinger (ORCID: https://orcid.org/0009-0003-8628-5536)
- Ioannis I. Verginadis (ORCID: https://orcid.org/0000-0002-0755-4511)
- Zev A. Binder (ORCID: https://orcid.org/0000-0003-1158-231X)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Subhajyoti De (ORCID: https://orcid.org/0000-0002-2313-8593)
- Tapan Ganguly
- Spyridon Bakas (ORCID: https://orcid.org/0000-0001-8734-6482)
- MacLean P. Nasrallah (ORCID: https://orcid.org/0000-0003-4861-0898)
- Chiharu Sako (ORCID: https://orcid.org/0000-0003-3243-3954)
- Donald M. O’Rourke (ORCID: https://orcid.org/0000-0002-8479-7314)
- Suyash Mohan (ORCID: https://orcid.org/0000-0002-4025-115X)
- Vikas Bommineni (ORCID: https://orcid.org/0000-0003-1544-2592)
- Constantinos Koumenis (ORCID: https://orcid.org/0000-0001-5945-4726)
- Hamed Akbari (ORCID: https://orcid.org/0000-0001-9786-3707)
- Artemis G. Hatzigeorgiou (ORCID: https://orcid.org/0000-0003-1414-5668)
- Elizabeth Mamourian (ORCID: https://orcid.org/0000-0001-8581-4887)
Institutions
- Rutgers, The State University of New Jersey (US)
- Children's Hospital of Philadelphia (US)
- University of Thessaly (GR)
- Santa Clara University (US)
- Cornell University (US)
- Pasteur Hellenic Institute (GR)
- Neurological Surgery (US)
- Weill Cornell Medicine (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1038/s43856-025-00767-0
- Citations
- 8
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 13.00