13-Methylpalmatine alleviates bleomycin-induced pulmonary fibrosis by suppressing the ITGA5/TGF-β/Smad signaling pathway
To our best knowledge, these results provide the first insight that 13-Me-PLT is protective against BLM-induced IPF in mice. Unlike existing antifibrotic drugs, 13-Me-PLT specifically targets the ITGA5/TGF-β/Smad signaling pathway, offering a novel and potentially more effective therapeutic approach. This study not only validates the antifibrotic efficacy of 13-Me-PLT but also elucidates its unique mechanism of action, these findings may provide an opportunity to develop new drugs to treat IPF.
Authors
- Haijing Li (ORCID: https://orcid.org/0000-0001-9332-8993)
- Mingyang Xu
- Jiajing Liu (ORCID: https://orcid.org/0000-0003-3268-6070)
- Zefeng Jiang
- Xiaowei Wen
- Miao Zhang (ORCID: https://orcid.org/0000-0002-6511-7192)
- Baofeng Yang (ORCID: https://orcid.org/0000-0002-0125-1608)
- Zhuo Wang (ORCID: https://orcid.org/0000-0003-1248-245X)
- Rong Zhang (ORCID: https://orcid.org/0000-0003-0006-3303)
- Yu Yan (ORCID: https://orcid.org/0000-0001-6697-5482)
- Qin Mao
- Gang Wang (ORCID: https://orcid.org/0000-0001-8962-1468)
- Jing Li (ORCID: https://orcid.org/0009-0003-6354-6975)
Institutions
- Harbin Medical University (CN)
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.phymed.2025.156545
- Citations
- 3
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- Beijing University of Chinese Medicine