Toll-Like Receptor 4 and 8 are Overexpressed in Lung Biopsies of Human Non-small Cell Lung Carcinoma
Albeit the precise role of TLRs is not fully defined, this study identified the potential involvement of TLR4 and TLR8 in the pathogenesis of NSCLC. Our data led us to hypothesize their potential role in overall survival which deserves to be explored further to establish whether TLR4 and TLR8 can represent positive prognostic indicators of disease in NSCLC.
Authors
- Giovanna Traina (ORCID: https://orcid.org/0000-0001-9996-3584)
- Carmela Conte (ORCID: https://orcid.org/0000-0003-2456-6300)
- Francesco Puma (ORCID: https://orcid.org/0000-0002-6861-168X)
- Claudia Floridi
- Luigi Cari (ORCID: https://orcid.org/0000-0003-0698-3872)
- Davide Petri (ORCID: https://orcid.org/0000-0002-3690-4007)
- Giuseppe Nocentini (ORCID: https://orcid.org/0000-0002-5209-0488)
- Jacopo Vannucci (ORCID: https://orcid.org/0000-0002-9014-1768)
- Guido Bellezza (ORCID: https://orcid.org/0000-0002-6337-1701)
- Silvia Ceccarelli (ORCID: https://orcid.org/0000-0002-1992-4495)
- Viola Pasqua Marzolesi
Institutions
- University of Perugia (IT)
Publication Details
- Journal
- Lung
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1007/s00408-025-00793-8
- Citations
- 3
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Università degli Studi di Perugia