Causal Effects From Kidney Function to Plasma Proteome: Integrated Observational and Mendelian Randomization Analysis With >50,000 UK Biobank Participants
In this proteo-genomic analysis, we identified 383 plasma proteins causally associated with eGFR, highlighting TNF-associated pathways as pathologically relevant processes in kidney disease progression, systemic inflammation, and organ fibrosis, warranting further investigation.
Authors
- Yaerim Kim (ORCID: https://orcid.org/0000-0003-1596-1528)
- Jeong Min Cho (ORCID: https://orcid.org/0000-0001-7643-994X)
- Jaeik Oh
- Seung Seok Han (ORCID: https://orcid.org/0000-0003-0137-5261)
- Jung Hun Koh (ORCID: https://orcid.org/0000-0001-7373-5487)
- Minsang Kim (ORCID: https://orcid.org/0000-0002-7949-0764)
- Sehoon Park (ORCID: https://orcid.org/0000-0002-4221-2453)
- Kwon Wook Joo (ORCID: https://orcid.org/0000-0001-9941-7858)
- Semin Cho (ORCID: https://orcid.org/0000-0002-6060-9032)
- Dong Ki Kim (ORCID: https://orcid.org/0000-0002-5342-1197)
- Soojin Lee (ORCID: https://orcid.org/0000-0002-0383-5025)
- Kwangsoo Kim (ORCID: https://orcid.org/0000-0002-4586-5062)
- Yong Chul Kim (ORCID: https://orcid.org/0000-0002-8461-5322)
- Yon Su Kim (ORCID: https://orcid.org/0000-0003-3091-2388)
- Hajeong Lee
Institutions
- Seoul National University (KR)
- Eulji University (KR)
- Seoul National University Hospital (KR)
- Keimyung University (KR)
- Chung-Ang University (KR)
Publication Details
- Journal
- PROTEOMICS - CLINICAL APPLICATIONS
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1002/prca.70002
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Korea Health Industry Development Institute