Adrenaline enhances nociceptive and motor blockades by intrathecal carteolol and oxprenolol in rats
Carteolol and oxprenolol are more effective than propranolol on spinal blockades, while other beta-blockers are relatively ineffective. Compared to propranolol, the duration of action of carteolol and oxprenolol is longer or the same. Epinephrine enhances spinal blockades of carteolol, oxprenolol, and propranolol, suggesting that alpha-adrenergic receptors may play an important role in enhancing the anti-nociceptive effects of beta-blockers.
Authors
- Chieh‐Yu Liu (ORCID: https://orcid.org/0000-0003-3283-028X)
- Ching‐Hsia Hung (ORCID: https://orcid.org/0000-0001-6316-4342)
- J. J. Wang
- Yu‐Wen Chen (ORCID: https://orcid.org/0000-0001-7560-2127)
- Chong‐Chi Chiu (ORCID: https://orcid.org/0000-0002-1696-2648)
- Kuo‐Sheng Liu (ORCID: https://orcid.org/0000-0003-4631-6011)
Institutions
- Tri-Service General Hospital (TW)
- China Medical University (TW)
- Chi Mei Medical Center (TW)
- Chia Nan University of Pharmacy and Science (TW)
- National Defense Medical Center (TW)
- National Cheng Kung University (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Fundamental and Clinical Pharmacology
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1111/fcp.70003
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- I-Shou University
- China Medical University, Taiwan
- National Science and Technology Council