Changing Epidemiology of Pediatric Pulmonary Exacerbations in Cystic Fibrosis
The decline in hospitalizations for pulmonary exacerbations likely reflects the benefits of ETI therapy, as a higher proportion of children and young adults hospitalized in 2022 had two non-F508del mutations and were not eligible for ETI. A greater percentage of those hospitalized in 2022 identified as belonging to minority racial groups, highlighting ongoing health disparities in the ETI era. Additionally, there were notable changes in the microbiological characteristics between 2018 and 2022.
Authors
- Julie Ryu
- Mohamoud Ahmed
- Tim Vigers (ORCID: https://orcid.org/0000-0001-7087-8570)
- Elizabeth B. Burgener (ORCID: https://orcid.org/0000-0001-8969-6232)
- Jonathan D. Cogen (ORCID: https://orcid.org/0000-0002-0382-6858)
- Andrea Hahn (ORCID: https://orcid.org/0000-0002-5117-0080)
- Antonio Arrieta (ORCID: https://orcid.org/0000-0001-9281-8915)
- Kathryn Akong
- Yaron Fireizen (ORCID: https://orcid.org/0000-0003-2942-490X)
- Pornchai Tirakitsoontorn (ORCID: https://orcid.org/0000-0003-0510-6165)
- Hani Fanous (ORCID: https://orcid.org/0000-0001-7548-7624)
- Scott D. Sagel (ORCID: https://orcid.org/0000-0001-6172-4465)
- Drake C. Bouzek (ORCID: https://orcid.org/0000-0002-8418-3072)
- E. Hanley
- Anastassios C. Koumbourlis (ORCID: https://orcid.org/0000-0002-4400-4885)
- John S. Bradley
- Jonathan L. Koff (ORCID: https://orcid.org/0000-0003-3240-3173)
- A. Keck
- D. M. STOUT
Institutions
- University of Southern California (US)
- George Washington University Hospital (US)
- Seattle Children's Hospital (US)
- Children's Hospital of Orange County (US)
- Children's National (US)
- Children's Hospital of Los Angeles (US)
- Colorado School of Public Health (US)
- University of Washington (US)
- University of California, Irvine (US)
- Yale University (US)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Children's Hospital Colorado (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Pediatric Pulmonology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1002/ppul.71019
- Citations
- 2
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 3.04