Identification of Schizophrenia‐Risk Regulatory Variant rs1399178 in the Non‐coding Region With Its Impact on <scp>NRF1</scp> Binding
Based on our data, a model is proposed in which rs1399178 confers schizophrenia risk by modifying NRF1 binding profiles, thereby regulating the abundance of target genes through promoter-enhancer switching. This study provides novel insights into the regulatory mechanisms of schizophrenia risk variants, highlighting the intricate nature of genetic interactions and potential therapeutic targets.
Authors
- Lei Ji (ORCID: https://orcid.org/0000-0003-3205-8541)
- Xiaoxi Wei (ORCID: https://orcid.org/0000-0002-4387-9161)
- Fan Yuan (ORCID: https://orcid.org/0000-0002-4759-5625)
- Yan Bi (ORCID: https://orcid.org/0000-0001-9733-9104)
- Liangjie Liu
- Decheng Ren (ORCID: https://orcid.org/0000-0002-1746-0623)
- Yi Shi (ORCID: https://orcid.org/0000-0002-5279-3239)
- Zhiqiang Li (ORCID: https://orcid.org/0000-0002-0174-9254)
- Qing Lu (ORCID: https://orcid.org/0000-0002-0123-6790)
- Ke Han (ORCID: https://orcid.org/0000-0002-6363-0638)
- Bo Huang (ORCID: https://orcid.org/0000-0003-1327-6586)
- Keyi Li (ORCID: https://orcid.org/0009-0009-6880-2433)
- Tao Yu (ORCID: https://orcid.org/0000-0003-2333-7282)
- Xingwang Li
- Lin He (ORCID: https://orcid.org/0000-0003-1079-1195)
- Guang He
- Fengping Yang
Institutions
- Qingdao University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Mental Health Center (CN)
- Affiliated Hospital of Qingdao University (CN)
- First People's Hospital of Chongqing (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1111/cns.70275
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanghai Leading Academic Discipline Project
- National Key Research and Development Program of China