Cardiovascular Risk Predicts White Matter Hyperintensities, Brain Atrophy and Treatment Resistance in Major Depressive Disorder: Role of Genetic Liability
These results underscore the need to explore cardiovascular risk management as part of treatment strategies for depression, pointing toward a shared pathophysiological process linking heart and brain health in treatment-resistant depression.
Authors
- Raffaella Zanardi (ORCID: https://orcid.org/0000-0001-5941-5663)
- Cristina Lorenzi (ORCID: https://orcid.org/0000-0002-3324-1359)
- Melania Maccario
- Cristina Colombo (ORCID: https://orcid.org/0000-0001-7310-7341)
- Francesco Benedetti (ORCID: https://orcid.org/0000-0003-4949-856X)
- Federico Calesella (ORCID: https://orcid.org/0000-0001-7481-4064)
- Sara Spadini (ORCID: https://orcid.org/0000-0002-7059-8242)
- Marco Paolini (ORCID: https://orcid.org/0000-0001-5731-5925)
- V. Saredi
- Sara Poletti
- Laura Raffaelli (ORCID: https://orcid.org/0009-0007-3295-0907)
- Anna Verri
Institutions
- Vita-Salute San Raffaele University (IT)
- IRCCS Ospedale San Raffaele (IT)
Publication Details
- Journal
- Acta Psychiatrica Scandinavica
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1111/acps.13793
- Citations
- 1
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- European Commission
- Ministero della Salute