Assisted reproduction and the fetal malformation risk associated with antiseizure medication exposure in pregnancy
WWE undertaking pregnancy through ART should be aware of the increased risk of fetal malformation beyond that related to ASM exposure. If this finding is supported in further studies, evaluations of fetal malformation risk rates associated with ASM exposure may need to be adjusted for possible overestimation because of confounder effects of ART, if ART was involved in the pregnancies studied.
Authors
- Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
- Piero Perucca (ORCID: https://orcid.org/0000-0002-7855-7066)
- Alison Anne Hitchcock (ORCID: https://orcid.org/0009-0007-3611-8819)
- Janet Elizabeth Graham (ORCID: https://orcid.org/0000-0003-2140-2351)
- Mervyn J. Eadie (ORCID: https://orcid.org/0000-0003-3791-9101)
- Frank Vajda (ORCID: https://orcid.org/0000-0001-5570-7538)
- Cecilie Margaret Lander (ORCID: https://orcid.org/0000-0002-3548-9550)
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Royal Brisbane and Women's Hospital (AU)
- Alfred Health (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1111/epi.18335
- Citations
- 3
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- Jazz Pharmaceuticals
- Royal Melbourne Hospital Neuroscience Foundation
- Epilepsy Society of Australia
- National Health and Medical Research Council
- UCB Pharma