Blocking the innate immune <scp>CD1d</scp> / <scp>NKT</scp> cell axis prevents the development of cortical hyperexcitability and posttraumatic epilepsy
Neuroinflammation initiated by the CD1d/NKT cell axis is involved in the development of cortical hyperexcitability and PTE; early treatment with simvastatin following a TBI exerts a prophylactic effect on posttraumatic epileptogenesis by blocking this axis.
Authors
- Raj Priya (ORCID: https://orcid.org/0000-0002-9272-9207)
- Xiaoming Jin (ORCID: https://orcid.org/0000-0002-8671-8640)
- Xingjie Ping (ORCID: https://orcid.org/0000-0001-8233-9961)
- Randy R. Brutkiewicz (ORCID: https://orcid.org/0000-0002-7396-480X)
- Season K. Wyatt‐Johnson (ORCID: https://orcid.org/0000-0001-8530-7885)
- Jianyun Liu (ORCID: https://orcid.org/0000-0002-6731-0375)
- Wenhui Xiong
Institutions
- Neurological Surgery (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1111/epi.18332
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- U.S. Department of Defense
- Indiana State Department of Health
- Congressionally Directed Medical Research Programs