The tau isoform 1N4R confers vulnerability of <i>MAPT</i> knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction
Tau knockout alters neurite growth and axon initial segment formation in human neurons. Tau isoforms show differential axonal localization in human neurons. Tau depletion protects against amyloid beta oligomer (AβO)-mediated neurotoxicity. 1N4R tau mediates AβO-induced toxicity in human neurons.
Authors
- Audrey Coulon (ORCID: https://orcid.org/0000-0002-2045-8364)
- Natja Haag (ORCID: https://orcid.org/0000-0002-2482-5969)
- Mohamed Aghyad Al Kabbani (ORCID: https://orcid.org/0000-0001-6200-2448)
- Sarah Buchholz (ORCID: https://orcid.org/0000-0002-3636-1364)
- Lena Kluge
- Devrim Kilinc (ORCID: https://orcid.org/0000-0003-3321-5203)
- Jennifer Klimek
- Hans Zempel (ORCID: https://orcid.org/0000-0002-7510-3077)
- Marcos R. Costa (ORCID: https://orcid.org/0000-0002-4928-2163)
- Michael J. Bell (ORCID: https://orcid.org/0000-0003-0681-901X)
- Lukas Cruz Carvalho Iohan
- Cagla Cagmak
Institutions
- Inserm (FR)
- University of Cologne (DE)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Universidade Federal do Rio Grande do Norte (BR)
- University Hospital Cologne (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1002/alz.14403
- Citations
- 12
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.81
Funders
- Jürgen Manchot Stiftung
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Studienstiftung des Deutschen Volkes