Increased nuchal translucency thickness and normal chromosomal microarray: Danish nationwide cohort study
Our study reaffirms the association between increased NT and chromosomal aberrations. Although CMA improves diagnostic resolution in pregnancies with increased NT, a normal test result does not substantially impact the prevalence of unaffected live births. This highlights the ongoing need for accurate clinical guidance and continued research, especially as whole-genome sequencing is increasingly adopted in prenatal care. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Authors
- Nis Brix (ORCID: https://orcid.org/0000-0002-1499-8401)
- Olav Bjørn Petersen (ORCID: https://orcid.org/0000-0001-8517-4082)
- Kasper Gadsbøll (ORCID: https://orcid.org/0000-0002-1331-3503)
- Ida Vogel (ORCID: https://orcid.org/0000-0002-1125-0393)
- Athena P. Souka (ORCID: https://orcid.org/0000-0002-8100-5983)
- Puk Sandager (ORCID: https://orcid.org/0000-0001-7153-7081)
- Kypros H. Nicolaides (ORCID: https://orcid.org/0000-0003-1266-0711)
Institutions
- University of Copenhagen (DK)
- National and Kapodistrian University of Athens (GR)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Alexandra Hospital (GR)
- Harris Birthright Research Centre for Fetal Medicine (GB)
- King's College Hospital (GB)
Publication Details
- Journal
- Ultrasound in Obstetrics and Gynecology
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1002/uog.29198
- Citations
- 10
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 34.94
Funders
- Novo Nordisk Fonden