Polygenic Risk Score Combined with Transcranial Sonography Refines Parkinson's Disease Risk Prediction
Our findings indicate that TCS-measured SN hyperechogenicity is associated with PD-PRS and olfactory impairment. This combined assessment may improve early diagnosis of prodromal PD by pinpointing individuals at increased risk.
Authors
- Mart Kals (ORCID: https://orcid.org/0000-0003-2090-8780)
- Toomas Toomsoo (ORCID: https://orcid.org/0009-0007-9561-5786)
- Mariliis Vaht (ORCID: https://orcid.org/0000-0002-5733-7056)
- Anu Reigo (ORCID: https://orcid.org/0009-0008-0226-3396)
- Maris Teder‐Laving (ORCID: https://orcid.org/0000-0002-5872-1850)
- Tiit Nikopensius (ORCID: https://orcid.org/0000-0002-0816-7804)
- Andres Metspalu (ORCID: https://orcid.org/0000-0002-3718-796X)
Institutions
- Tallinn University (EE)
- North Estonia Medical Centre (EE)
- University of Tartu (EE)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1002/mdc3.70011
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Haridus- ja Teadusministeerium
- European Regional Development Fund