Single-cell transcriptome sequencing reveals the immune microenvironment in bronchoalveolar lavage fluid of checkpoint inhibitor-related pneumonitis
Utilizing single-cell sequencing of BALF, we discovered an enriched population of aberrant basaloid cells in CIP-S patients, which had not been previously reported. Aberrant basaloid cells may upregulate SOX9 via CXCL3/5-CXCR2 to recruit and activate neutrophils, and further activate the immune system, resulting in CIP-S. This finding could identify new targets for stratified treatment of CIP patients, holding promise of a novel approach for clinical guidance.
Authors
- Xiewan Chen (ORCID: https://orcid.org/0009-0002-1588-2088)
- Feng-Lin Lin
- Chenrui Yin
- Longyao Zhang (ORCID: https://orcid.org/0000-0002-0687-8397)
- Jianguo Sun (ORCID: https://orcid.org/0000-0002-4855-3689)
- Linpeng Zheng
- Lingyou Sun
- Jianbo Zhu (ORCID: https://orcid.org/0000-0002-9385-4958)
- Dingqin Cai
- Yiying Qi (ORCID: https://orcid.org/0000-0003-1535-279X)
- Lingchen Li (ORCID: https://orcid.org/0000-0003-2783-426X)
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1007/s00262-025-03983-8
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China