Longitudinal analysis of retinal and choriocapillaris in patients with multiple sclerosis: a 3-year study
This study demonstrates progressive retinal neurodegeneration and microvascular dysfunction in patients with RRMS without a history of optic neuritis. The association between ONL thinning and increased disability supports the potential of OCT/OCTA as valuable tools for monitoring disease progression and severity in RRMS.
Authors
- Mihai Bostan (ORCID: https://orcid.org/0009-0007-4996-2656)
- Leopold F. Schmetterer (ORCID: https://orcid.org/0000-0002-7189-1707)
- Damon Wing Kee Wong (ORCID: https://orcid.org/0000-0003-4601-9121)
- Jacqueline Chua (ORCID: https://orcid.org/0000-0002-6474-5293)
- Munirah Ismail (ORCID: https://orcid.org/0000-0001-8171-9911)
- Ruxandra Coroleucă (ORCID: https://orcid.org/0009-0007-3623-9813)
- Gerhard Garhöfer (ORCID: https://orcid.org/0000-0001-5547-5669)
- Bingyao Tan (ORCID: https://orcid.org/0000-0002-6532-9603)
- Alina Popa‐Cherecheanu (ORCID: https://orcid.org/0000-0003-4189-6571)
- Chi Li (ORCID: https://orcid.org/0000-0003-4813-3729)
- Jia Wei Cheong
Institutions
- Carol Davila University of Medicine and Pharmacy (RO)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Singapore National Eye Center (SG)
- Clinical Emergency Hospital Bucharest (RO)
- Emergency University (US)
- Singapore Eye Research Institute (SG)
- Fondation Ophtalmologique Adolphe de Rothschild (FR)
- Duke-NUS Medical School (SG)
- Institute of Molecular and Clinical Ophthalmology Basel (CH)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1007/s00415-025-12930-7
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Duke-NUS Medical School
- National Research Foundation
- Agency for Science, Technology and Research
- National Research Foundation Singapore
- Singapore Eye Research Institute
- Nanyang Technological University
- Medical Research Council
- National Medical Research Council