Reflexive and voluntary saccades as a proxy for bradykinesia and apathy in Parkinson’s disease
While the saccade period best correlates with bradykinesia, maximal amplitude in the absence of cue better reflects the severity of apathy. Our paradigm may be a promising objective biomarker for assessing bradykinesia and apathy in PD.
Authors
- Radek Ptak (ORCID: https://orcid.org/0000-0003-4708-9201)
- Paul Krack (ORCID: https://orcid.org/0000-0002-3508-7295)
- Diego Kaski (ORCID: https://orcid.org/0000-0002-0591-646X)
- Damien Benis (ORCID: https://orcid.org/0000-0003-3325-7884)
- F. van Rey
- André Zacharia (ORCID: https://orcid.org/0000-0002-3011-4792)
- Matthieu Béreau (ORCID: https://orcid.org/0000-0003-0769-0289)
- René M. Müri (ORCID: https://orcid.org/0000-0001-6990-4188)
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
- Centre Hospitalier Universitaire de Besançon (FR)
- Berner Augenklinik am Lindenhofspital (CH)
- University Hospital of Geneva (CH)
- Université Bourgogne Franche-Comté (FR)
- National Hospital for Neurology and Neurosurgery (GB)
- Hôpital de la Tour (CH)
- French Clinical Research Infrastructure Network (FR)
- University College London (GB)
- Geneva College (US)
- University of Lausanne (CH)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1007/s00415-025-12973-w
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Fondation Centre de Recherches Médicales Carlos et Elsie de Reuter