Studying the Effect of 12 Weeks of Resistance Training with Sumac Supplementation on Inflammatory and Apoptotic Indices in Male Alzheimer's Mice

Introduction: Alzheimer's disease represents the most prevalent form of dementia, characterized by a gradual decline in memory function. This study aimed to examine the impact of 12 weeks of resistance training combined with sumac supplementation on various inflammatory and apoptotic markers in the serum of male rats exhibiting Alzheimer's disease. Methods: In this experimental study, 35 rats were randomly divided into five groups: control, Alzheimer's, Alzheimer's + sumac supplement, Alzheimer's + resistance training, and Alzheimer's + resistance training + sumac supplement. To induce Alzheimer's, 8 mg/kg of trimethyltin chloride was administered to the rats along with 200μl of normal saline. Sumac was added to the food of the subjects at a rate of 10% and was freely available to them. Resistance training was performed for 12 weeks, five times a week, in the form of climbing a ladder with weights attached to their tails, one meter long, with 26 steps and an angle of 85 degrees. Then, the rats were sacrificed and blood samples were taken. IL-18 and Cas3 were examined using the ELISA method. IL-18 and Cas3 were examined using ELISA. The data results were analyzed using one-way ANOVA with Tukey's post hoc test at a significance level (p<0.0001) using SPSS software version 16. Results: The findings indicated that a period of resistance training along with sumac supplementation significantly reduced the levels of interleukin 18 and caspase 3 (p<0.0001). However, sumac supplementation alone, as well as resistance training alone, significantly reduced the expression of caspase 3 protein (p<0.0001), but had no significant effect on the levels of interleukin 18 (p<0.05). Conclusion: Our findings showed that resistance training combined with sumac supplementation can improve the levels of inflammatory and apoptotic indices.