Comprehensive Analysis of Multi-Omics Data on RNA Polymerase as an Adverse Factor in Head and Neck Squamous Cell Carcinoma
This study highlights the dual role of POLRs in promoting malignant proliferation and shaping an immunosuppressive TME. POLR2C, regulated by YY1, emerges as a critical mediator in HNSC and a promising target for precision therapies.
Authors
- Yuan‐jie Liu (ORCID: https://orcid.org/0000-0001-5062-555X)
- Q. X. Geng (ORCID: https://orcid.org/0000-0002-5124-8095)
- Yue Gu (ORCID: https://orcid.org/0000-0002-3852-9319)
- Qian Zhang (ORCID: https://orcid.org/0000-0002-2791-5599)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-1397-5224)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jir.s496748
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81