A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity
This work was funded by grants from the e-Asia Joint Research Program (N10A650706 and N10A660577 to MLM, in collaboration with SS); the NIH (U19 AI142790-02S1 to EOS and SS and R44 AI157900 to KJ); the GHR Foundation (to SS and EOS); the Overton family (to SS and EOS); the Arvin Gottlieb Foundation (to SS and EOS), the Prebys Foundation (to SS); and the American Association of Immunologists Fellowship Program for Career Reentry (to FASB).
Authors
- Shailendra Kumar Verma (ORCID: https://orcid.org/0000-0001-9142-3022)
- Norazizah Shafee (ORCID: https://orcid.org/0000-0002-6877-7612)
- Robyn L. Miller (ORCID: https://orcid.org/0000-0002-4679-7567)
- Meng Ling Moi (ORCID: https://orcid.org/0000-0002-8103-6659)
- Linda Tran (ORCID: https://orcid.org/0000-0002-7356-2878)
- Julia Timis
- Erin Maule
- David R. Webb
- Sujan Shresta (ORCID: https://orcid.org/0000-0003-2906-8474)
- Fernanda Ana‐Sosa‐Batiz
- Erica Ollmann Saphire (ORCID: https://orcid.org/0000-0002-1206-7451)
- Michelle Zandonatti (ORCID: https://orcid.org/0000-0002-6898-5235)
- Henry Madany
- Kathryn M. Hastie (ORCID: https://orcid.org/0000-0002-3406-1210)
- Kenneth Kim (ORCID: https://orcid.org/0000-0002-5993-4575)
- Kurt Jarnagin
- Michael N. Nguyen (ORCID: https://orcid.org/0000-0002-4184-7078)
- A. Street
- Chris Conner
- Krithik Varghese
Institutions
- La Jolla Institute for Immunology (US)
- Syneos Health (United States) (US)
- Department of Health (IE)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105619
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79