Identification of blood-derived exosomal tumor RNA signatures as noninvasive diagnostic biomarkers for multi-cancer: a multi-phase, multi-center study
The study demonstrates the robust potential of exosomal RNA as a minimally invasive biomarker resource for cancer detection. The developed ETR.sig platform offers a promising tool for precision oncology and broad-spectrum cancer screening, integrating advanced computational models with nanoscale vesicle biology for accurate and rapid diagnosis.
Authors
- Tianman Li
- Zuheng Wang
- Linjian Mo (ORCID: https://orcid.org/0000-0003-1040-7667)
- Jiwen Cheng (ORCID: https://orcid.org/0000-0001-5907-9436)
- Tianyu Li (ORCID: https://orcid.org/0000-0003-0833-8762)
- Duobing Zhang
- Weimin Lu
- Wenhao Lu (ORCID: https://orcid.org/0000-0001-8660-2886)
- Jin‐Kun Wen (ORCID: https://orcid.org/0000-0002-8453-4549)
- Shaohua Chen (ORCID: https://orcid.org/0000-0003-3544-3138)
- Xing He (ORCID: https://orcid.org/0000-0001-7676-9930)
- Zengnan Mo (ORCID: https://orcid.org/0000-0002-3047-3138)
- Fubo Wang (ORCID: https://orcid.org/0000-0002-2209-9932)
- Jin Ji (ORCID: https://orcid.org/0000-0002-2985-8372)
- Shenglin Huang (ORCID: https://orcid.org/0000-0003-1279-0794)
- Rongbin Zhou (ORCID: https://orcid.org/0000-0002-3351-6420)
- Guijian Pang
- Liu Ouyang (ORCID: https://orcid.org/0000-0002-3695-571X)
- Lin Zhao (ORCID: https://orcid.org/0000-0002-4016-3176)
- Chengbang Wang
- Li Xiao (ORCID: https://orcid.org/0000-0002-3627-2513)
- Leifeng Liang (ORCID: https://orcid.org/0000-0003-1935-4100)
- Shaohua Zhang (ORCID: https://orcid.org/0000-0002-3911-2398)
- Yan Liu (ORCID: https://orcid.org/0000-0002-3961-9172)
- Yifeng Chen (ORCID: https://orcid.org/0000-0003-3010-994X)
- Tingting Li (ORCID: https://orcid.org/0000-0003-2754-9784)
- Zhe Liu (ORCID: https://orcid.org/0000-0001-5796-4335)
- Zehui Chen (ORCID: https://orcid.org/0000-0003-4055-3008)
- Xing Li (ORCID: https://orcid.org/0000-0001-6469-4839)
- Zhenguang Wang (ORCID: https://orcid.org/0000-0003-2001-5165)
- Xiaolei Shi (ORCID: https://orcid.org/0000-0001-9650-7567)
- Bin Xu (ORCID: https://orcid.org/0009-0000-6745-817X)
- Wenxuan Zhou
- Meimei Li (ORCID: https://orcid.org/0000-0003-2035-0406)
- Fuchen Liu
- Huiyong Zhang (ORCID: https://orcid.org/0000-0003-0509-0693)
- Bo Yang (ORCID: https://orcid.org/0000-0003-4685-8515)
- Xuedong Wei (ORCID: https://orcid.org/0000-0003-2000-2620)
- Fang Yu (ORCID: https://orcid.org/0009-0004-2747-3972)
- Xiangui Hu
- Chunmeng Wei (ORCID: https://orcid.org/0000-0002-7303-969X)
- Qingyun Zhang
- Yonggang Hong
- Li Wang (ORCID: https://orcid.org/0000-0003-2068-7535)
Institutions
- Guangxi Medical University (CN)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- Nantong University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Soochow University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Ninth People's Hospital (CN)
- People's Liberation Army 401 Hospital (CN)
- Changhai Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- General Hospital of Shenyang Military Region (CN)
- Shanghai First People's Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Tumor Hospital of Guangxi Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s12943-025-02271-4
- Citations
- 19
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 15.31
Funders
- National Natural Science Foundation of China