cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia
Our study reveals a mechanism for cGAMP-mediated iBRB breakdown and suggests that targeting microglia and P2RX7 may mitigate the deleterious effects of STING activation in retinal diseases linked to iBRB impairment.
Authors
- Xiangyu Ge (ORCID: https://orcid.org/0000-0001-5956-8870)
- Mi Deng (ORCID: https://orcid.org/0000-0003-4291-0144)
- Ju Rong (ORCID: https://orcid.org/0000-0003-0494-110X)
- Lili Gong (ORCID: https://orcid.org/0000-0002-3129-3868)
- Ziqing Chen (ORCID: https://orcid.org/0000-0001-5077-2250)
- Zhaotian Zhang (ORCID: https://orcid.org/0000-0003-0436-3338)
- Wei Liu (ORCID: https://orcid.org/0000-0001-9439-5100)
- Xiangcheng Tang (ORCID: https://orcid.org/0009-0001-2338-3388)
- Xiaoyan Ding
- Mingsen Li (ORCID: https://orcid.org/0000-0002-6950-4755)
- Haifeng Cui
- Xuebin Hu
- Xingfei Zhu (ORCID: https://orcid.org/0000-0002-4719-0353)
- Ming Zou
- Li Wang (ORCID: https://orcid.org/0000-0002-0496-9500)
Institutions
- Sun Yat-sen University (CN)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Peking University International Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s12974-025-03391-w
- Citations
- 15
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 16.77
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province