IRF1 is a core transcriptional regulatory circuitry member promoting AML progression by regulating lipid metabolism
In summary, this study identified IRF1 as a novel core transcription factor involved in AML pathogenesis. IRF1 collaborates with ELF1, ETV6, RUNX2, and MEF2D to form a core transcriptional regulatory circuit that promotes AML progression. Furthermore, we demonstrated that IRF1 directly regulates the expression of key genes involved in lipid metabolism, influencing the synthesis of diverse lipid molecules crucial for AML survival.
Authors
- Fenli Zhang
- Man Zhou (ORCID: https://orcid.org/0000-0002-6757-0265)
- Xiaoyan Yang (ORCID: https://orcid.org/0000-0003-3086-0792)
- Yumeng Wu (ORCID: https://orcid.org/0000-0001-7648-365X)
- Yixin Hu (ORCID: https://orcid.org/0009-0008-0960-929X)
- Ailian Guo
- Shaoyan Hu (ORCID: https://orcid.org/0000-0003-1285-9499)
- Bi‐Cheng Zhou (ORCID: https://orcid.org/0000-0003-1560-4950)
- Zhongling Wei (ORCID: https://orcid.org/0000-0002-2763-0964)
- Yizhen Li (ORCID: https://orcid.org/0000-0002-0762-7899)
- Zi-Mu Zhang (ORCID: https://orcid.org/0000-0002-7791-4252)
- Yi‐Jun Wu (ORCID: https://orcid.org/0000-0003-1064-2886)
- Ling Xu
- Xiaolu Li (ORCID: https://orcid.org/0009-0009-4673-2016)
- Fang Fang (ORCID: https://orcid.org/0000-0001-9829-2934)
- Yan Li (ORCID: https://orcid.org/0000-0003-4936-8917)
- Yongping Zhang (ORCID: https://orcid.org/0000-0003-2267-6434)
- Zhixu He (ORCID: https://orcid.org/0000-0002-8263-129X)
- Zhiheng Li (ORCID: https://orcid.org/0000-0002-1077-5278)
- Ying Yang (ORCID: https://orcid.org/0000-0002-6304-601X)
- Jian Pan (ORCID: https://orcid.org/0000-0002-1907-462X)
- Chunxia Yang (ORCID: https://orcid.org/0009-0000-8440-8481)
- Yanfang Tao
Institutions
- Guiyang Medical University (CN)
- Bengbu Medical College (CN)
- Xuzhou Medical College (CN)
- Anhui Medical University (CN)
- Soochow University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s40164-025-00612-z
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China