TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumors
Our study provides a novel approach to alleviate the potential safety concerns associated with eosinophils while increasing T-cell infiltration in solid tumors. This finding offers a prospective strategy for incorporating eosinophils to improve CAR-T-cell immunotherapy for solid tumors in the future.
Authors
- Qi Lei (ORCID: https://orcid.org/0000-0001-6246-8352)
- Minghao Yin (ORCID: https://orcid.org/0000-0002-6226-2394)
- Yingfeng Zhang (ORCID: https://orcid.org/0000-0001-9547-381X)
- Lejun Lv
- Zhengyang Zhou (ORCID: https://orcid.org/0000-0003-4728-7347)
- Tianxing Liu
- Jia You (ORCID: https://orcid.org/0000-0001-5941-8311)
- Riliang Gu (ORCID: https://orcid.org/0000-0002-7427-3680)
- Guo‐Kai Wang (ORCID: https://orcid.org/0000-0002-3924-6169)
- Chengyan Wang (ORCID: https://orcid.org/0000-0003-3982-6208)
- Hongkui Deng (ORCID: https://orcid.org/0000-0003-3045-4428)
- Cheng Jung Li (ORCID: https://orcid.org/0000-0001-6110-8099)
- Yudi Miao
- Sheng Zhu
- Yi Huo (ORCID: https://orcid.org/0000-0003-2144-4033)
- Zixin Zhao
- Chenyi Dai
Institutions
- Peking University (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s40164-025-00613-y
- Citations
- 5
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- National Natural Science Foundation of China