HLA Association With AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder in the Korean Population
In a Korean cohort of patients withAQP4-IgG NMOSD, the HLA-DRB1*12:02-DQB1*03:01 haplotype was associated with disease severity at onset. HLA-DRB1*03:01, broadly reported as a significant susceptibility allele across diverse ethnic groups, showed a significant risk association in Korean patients with AQP4-IgG NMOSD.
Authors
- Jangsup Moon (ORCID: https://orcid.org/0000-0003-1282-4528)
- Jae‐Won Hyun (ORCID: https://orcid.org/0000-0003-0288-771X)
- You‐Ri Kang
- Su‐Hyun Kim (ORCID: https://orcid.org/0000-0002-0679-0918)
- Ho Jin Kim (ORCID: https://orcid.org/0000-0002-8672-8419)
- Ki Hoon Kim (ORCID: https://orcid.org/0000-0001-6428-061X)
- Sinae Kim (ORCID: https://orcid.org/0000-0002-9900-492X)
- Na Young Park
Institutions
- Seoul National University Hospital (KR)
- Inje University Sanggye Paik Hospital (KR)
- National Cancer Center (KR)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1212/nxi.0000000000200366
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Biogen
- Alexion Pharmaceuticals
- National Research Foundation
- National Research Foundation of Korea
- Eisai