Evaluating the Effects of a 1000kcal Low Carbohydrate Diet and Panchakarma on Cardiovascular Risk Factors in Hypertriglyceridemia

Background: Elevated triglyceride (TG) levels are a significant risk factor for cardiovascular disease. This retrospective study investigates the impact of a 1000kcal/day low-carbohydrate diet, combined with Panchakarma, on TG levels in individuals with hypertriglyceridemia. Purpose: To evaluate the effectiveness of a 12-week intervention combining a 1000kcal/day low-carbohydrate diet and Panchakarma therapy in reducing triglyceride (TG) levels and improving other cardiometabolic parameters with hypertriglyceridemia. Methods: A retrospective, Multicentric, observational study was conducted from January 2024 to September 2024. A total of 52 patients aged 30-80 years with TG levels >150mg/dL and followed a 1000kcal low-carbohydrate diet for 12 weeks, with Panchakarma were included in this study. The primary endpoint was improvement in Cholesterol Levels from baseline to the 90-day follow-up. Secondary endpoints were improvement in weight, ABG (Abdominal Girth), Heart Rate and reduction in dependency on allopathic medication from baseline to the 90-day follow-up. Results: Mean age of the study was 53.37±14.17 years. Primary finding (Mean ± SD, Baseline Vs. 90-days): TG improved from 246.56±82.14 to 230.35±90.55, p=0.0 at the 90-day follow-up. Secondary endpoints of Weight (day 1: 75.60±13.64% and day 90: 72.78±13.01%, p=0.00), ABG (day 1: 101.02±10.66 and day 90: 97.46±9.22, p=0.00), Heart Rate (day 1: 81.98±12.56 and day 90: 77.87±11.46, p=0.03), and BMI parameters also improved at the 90-day follow-up. Reduction in allopathic medication doses was also observed. Conclusions: A 12-week intervention with a 1000kcal/day low-carbohydrate diet and Panchakarma displayed positive impact on reduced TG levels and various health parameters. Keywords: Hypertriglyceridemia, Low-Carbohydrate Diet, Triglycerides, Panchakarma, Ayurveda