Folium Hibisci Mutabilis extract suppresses M1 macrophage polarization through mitochondrial function enhancement in murine acute gouty arthritis
The therapeutic potential of FHME for AGA is associated with the maintenance of mitochondrial function to inhibit M1 macrophage polarization, which is intimately linked to the UQCRC1. Our findings highlight the potential of Folium Hibisci Mutabilis as a safe and effective approach for AGA.
Authors
- Haiyan He (ORCID: https://orcid.org/0000-0001-6713-6365)
- Min Jiang (ORCID: https://orcid.org/0000-0003-2946-6974)
- Honghong Ma (ORCID: https://orcid.org/0000-0002-0066-921X)
- Wei Yan (ORCID: https://orcid.org/0000-0002-1123-0835)
- Jiahui Zhang (ORCID: https://orcid.org/0009-0007-7234-4725)
- Yuxin Zhang (ORCID: https://orcid.org/0009-0003-4006-5992)
- Juncheng Li (ORCID: https://orcid.org/0000-0002-1904-4068)
- Yichen Zhao (ORCID: https://orcid.org/0000-0003-2443-9205)
- Ping Jiang (ORCID: https://orcid.org/0000-0002-3758-130X)
- Kai Yang (ORCID: https://orcid.org/0000-0003-3988-3034)
- Xiaobing Xi (ORCID: https://orcid.org/0000-0002-4372-8312)
Institutions
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s13020-025-01081-6
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Natural Science Foundation of China