Role of Neuropeptide B/W Signaling in Modulating Intracellular Calcium in Human Skin Fibroblasts

This finding suggests a potential role for the NPB/W signalling system in pathologies associated with impaired calcium handling, such as fibrosis. Furthermore, we observed that the proliferation of human fibroblasts was not affected by hNPB (25-53). Our findings could lead to the development of new therapeutic strategies for various skin conditions and improved wound healing.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2025-02-20
DOI
https://doi.org/10.31083/fbl26760
Primary Topic
Neurobiology and Insect Physiology Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Role of Neuropeptide B/W Signaling in Modulating Intracellular Calcium in Human Skin Fibroblasts

Dagmar Jarkovská, Radek Kučera, M Dvořáková, Shashank Pandey et al.
Frontiers in Bioscience-Landmark
Neurobiology and Insect Physiology Research
article

Role of Neuropeptide B/W Signaling in Modulating Intracellular Calcium in Human Skin Fibroblasts

Dagmar Jarkovská, Radek Kučera, M Dvořáková, Shashank Pandey, Olivier Monasson, Elisa Peroni, Michal Jirásko, Tomas Chmelir
article en

Abstract

This finding suggests a potential role for the NPB/W signalling system in pathologies associated with impaired calcium handling, such as fibrosis. Furthermore, we observed that the proliferation of human fibroblasts was not affected by hNPB (25-53). Our findings could lead to the development of new therapeutic strategies for various skin conditions and improved wound healing.

Frontiers in Bioscience-LandmarkVol. 30(2)
Centre National de la Recherche Scientifique (FR), Charles University (CZ), CY Cergy Paris Université (FR)
Zero hunger
Openalex Percentile: Top 95%
Neurobiology and Insect Physiology Research
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