CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis
Our study reveals a novel role of CTCF in regulating erythroid differentiation by maintaining its proper chromatin openness and gene expression network, which extends our understanding of CTCF biology.
Authors
- Jinchao Xu (ORCID: https://orcid.org/0000-0002-1530-6913)
- Judith Hyle
- Yang Xue (ORCID: https://orcid.org/0000-0002-0572-3086)
- Beisi Xu (ORCID: https://orcid.org/0000-0003-0099-858X)
- Cheng Li (ORCID: https://orcid.org/0000-0002-1286-9403)
- Wenjie Qi (ORCID: https://orcid.org/0009-0006-0656-567X)
- Wojciech Rosikiewicz (ORCID: https://orcid.org/0000-0001-7031-3430)
- Xin Ye (ORCID: https://orcid.org/0000-0002-9931-2041)
- Peng Xu (ORCID: https://orcid.org/0000-0002-7573-4813)
- Mengli Zhang (ORCID: https://orcid.org/0000-0003-4147-394X)
- Jianxiang Zhang (ORCID: https://orcid.org/0000-0002-0984-2947)
- Xinfeng Chen (ORCID: https://orcid.org/0000-0003-2579-273X)
- C-Q. Li
- Ruopeng Feng
Institutions
- St. Jude Children's Research Hospital (US)
- Soochow University (CN)
- Io Therapeutics (United States) (US)
Publication Details
- Journal
- Genome biology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s13059-025-03510-z
- Citations
- 7
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- American Lebanese Syrian Associated Charities
- National Natural Science Foundation of China