Influence of Injectable Hyaluronic Gel System on Skin Microbiota, Skin Defense Mechanisms and Integrity (Ex vivo Study)
Our investigation showed that both intradermal injections, HA-based solution or control excipient, trigger short-term skin microbiota growth. We indicate strong influence of non-sterile skin surface conditions on human skin explant viability when skin barrier damaged by injection puncture and highlights differences of epidermal/dermal response depended on injected composition.
Authors
- Laurent Peno‐Mazzarino (ORCID: https://orcid.org/0000-0003-1753-9355)
- Zarema Gazitaeva
- Nikita Radionov
- А. О. Дробинцева (ORCID: https://orcid.org/0000-0002-6833-6243)
- I. М. Kvetnoy (ORCID: https://orcid.org/0000-0001-7302-5581)
- Anna Sidorina
- Aleksei Prokopov (ORCID: https://orcid.org/0000-0001-8218-535X)
Institutions
- Ministry of Health of the Russian Federation (RU)
- Bioengineering Center (RU)
- Saint-Petersburg Research Institute of Phthisiopulmonology (RU)
- Eurofins (France) (FR)
- Saint Petersburg State Pediatric Medical University (RU)
Publication Details
- Journal
- Clinical Cosmetic and Investigational Dermatology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.2147/ccid.s491685
- Citations
- 2
- Primary Topic
- Facial Rejuvenation and Surgery Techniques
- Type
- article
- Field-Weighted Citation Impact
- 4.01