Adipose-derived stem cells enhance the tumorigenic potential of pre-malignant breast epithelial cells through paracrine activation of PI3K–AKT pathway
Our data illustrated the synergistic effect between ADSC paracrine factors and MCF-10AT auto-activated pathways in the carcinogenesis of MCF-10AT cells through activation of the oncogenic PI3K-AKT pathway. Based on these findings, we strongly recommend pre-operative examinations for breast cancer risk factors before ADSC-associated transplantation.
Authors
- Bao‐Fu Yu (ORCID: https://orcid.org/0000-0002-1952-0255)
- Yangxuanyu Yan
- Gang‐Ming Zou (ORCID: https://orcid.org/0000-0002-5953-5216)
- Xiaoxue Chen (ORCID: https://orcid.org/0000-0002-2077-6020)
- Qimin Zhou (ORCID: https://orcid.org/0000-0002-9480-4872)
- Qingfeng Li (ORCID: https://orcid.org/0000-0001-7822-618X)
- Chuanchang Dai
- Kai Liu (ORCID: https://orcid.org/0000-0003-3541-5954)
- Tanja Herrler
- Yunbo Qiao (ORCID: https://orcid.org/0000-0002-8391-5868)
- Wei Jiao (ORCID: https://orcid.org/0000-0003-1679-8021)
- Shengfang Ge (ORCID: https://orcid.org/0000-0002-8005-2462)
- Danning Zheng (ORCID: https://orcid.org/0000-0002-1056-7161)
- Jinguang He
- Qifeng Wu (ORCID: https://orcid.org/0000-0001-5249-5410)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai FRP Research Institute (China) (CN)
- Berufsgenossenschaftliche Unfallklinik Murnau (DE)
- Gannan Medical University (CN)
Publication Details
- Journal
- Breast Cancer
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1007/s12282-025-01686-7
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Massachusetts Institute of Technology
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Shanghai University of Traditional Chinese Medicine
- Jiangxi University of Traditional Chinese Medicine
- Key Research and Development Program of Jiangxi Province