The alternative polyadenylation regulator CFIm25 promotes macrophage differentiation and activates the NF-κB pathway
Our study establishes CFIm25 as a key mediator of macrophage differentiation that operates through a coordinated control of cell cycle progression and NF-κB signaling. This linkage of mRNA processing and immune cell function also expands our understanding of the role of alternative polyadenylation in regulating cell signaling.
Authors
- Lu‐Yang Wang (ORCID: https://orcid.org/0000-0002-5399-944X)
- Claire Moore (ORCID: https://orcid.org/0000-0002-1883-9459)
- Bin Tian (ORCID: https://orcid.org/0000-0001-8903-8256)
- Srimoyee Mukherjee (ORCID: https://orcid.org/0000-0002-7521-2812)
- Atish Barua
Institutions
- The Wistar Institute (US)
- Tufts University (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12964-025-02114-1
- Citations
- 7
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases