Brain age mediates gut microbiome dysbiosis-related cognition in older adults
Our findings indicate that brain age mediates the link between gut microbiome dysbiosis and cognitive performance. These insights suggest potential interventions targeting the gut microbiome to alleviate age-related cognitive decline.
Authors
- Hyun Woong Roh (ORCID: https://orcid.org/0000-0002-1333-358X)
- Helmet T. Karim (ORCID: https://orcid.org/0000-0002-9286-0694)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Jae Youn Cheong (ORCID: https://orcid.org/0000-0001-6246-1783)
- Chang Hyung Hong (ORCID: https://orcid.org/0000-0003-3258-7611)
- Sang Joon Son (ORCID: https://orcid.org/0000-0001-7434-7996)
- Cheol-O Kwon
- Chil-Sung Kang (ORCID: https://orcid.org/0000-0002-6357-2677)
- Antonija Kolobaric (ORCID: https://orcid.org/0000-0001-7326-585X)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- You Jin Nam (ORCID: https://orcid.org/0000-0002-6603-5586)
- Howard Jay Aizenstein (ORCID: https://orcid.org/0000-0003-4897-6582)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Yong Hyuk Cho (ORCID: https://orcid.org/0000-0002-2570-7278)
- Sunhwa Hong (ORCID: https://orcid.org/0000-0003-0268-6360)
- Eldin Jašarević (ORCID: https://orcid.org/0000-0001-8174-0710)
- Tae-Seop Shin (ORCID: https://orcid.org/0000-0002-8165-0595)
- Bumhee Park (ORCID: https://orcid.org/0000-0002-5271-1571)
- Maria Ly (ORCID: https://orcid.org/0000-0003-3546-0149)
- Carmen Andreescu (ORCID: https://orcid.org/0000-0003-3767-5127)
- Jin Wook Choi (ORCID: https://orcid.org/0000-0002-2396-4705)
- Narae Kim (ORCID: https://orcid.org/0000-0001-7354-5974)
- Dongyun Lee (ORCID: https://orcid.org/0000-0002-3977-3663)
- Seo-Yoon Yoon
- Yoon-Keun Kim
Institutions
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- Allegheny General Hospital (US)
- Magee-Womens Research Institute (US)
- Mallinckrodt (United States) (US)
- Ajou University (KR)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s13195-025-01697-8
- Citations
- 7
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Korea Disease Control and Prevention Agency
- Korea Health Industry Development Institute
- National Research Foundation of Korea