Inferring protein from transcript abundances using convolutional neural networks
For H. sapiens, our model improves prediction performance by nearly 50% compared to previous sequence-based approaches, and for A. thaliana it represents the first model of its kind. The model's learned motifs recapitulate known regulatory elements, supporting its utility in systems-level and hypothesis-driven research approaches related to protein regulation.
Authors
- Patrick Schwehn
- Pascal Falter‐Braun (ORCID: https://orcid.org/0000-0003-2012-6746)
Institutions
- Target (Germany) (DE)
Publication Details
- Journal
- BioData Mining
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s13040-025-00434-z
- Citations
- 4
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.03
Funders
- Bundesministerium für Bildung und Forschung
- Horizon 2020 Framework Programme