FlaA N/C attenuates radiation-induced lung injury by promoting NAIP/NLRC4/ASC inflammasome autophagy and inhibiting pyroptosis
These results indicate that FlaA N/C attenuates RILI by promoting NAIP/NLRC4/ASC inflammasome autophagy and inhibiting pyroptosis. This study provides a potential approach for RILI intervention.
Authors
- Qing Yin (ORCID: https://orcid.org/0000-0002-8875-5488)
- Shihua Deng
- Kejian Pan (ORCID: https://orcid.org/0000-0002-9172-157X)
- Ying Xin Xu (ORCID: https://orcid.org/0000-0001-9570-8666)
- Yueyan Yang
- Xun Xia (ORCID: https://orcid.org/0000-0003-0422-5963)
- Teng Liu (ORCID: https://orcid.org/0000-0002-2185-7260)
- Ting Zhang (ORCID: https://orcid.org/0000-0002-0488-2755)
- Shuang He
- Zixin Chen (ORCID: https://orcid.org/0000-0002-7288-7830)
- Dongming Wu (ORCID: https://orcid.org/0000-0002-0665-4422)
Institutions
- Chengdu Medical College (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s12967-025-06257-0
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China