Relationship of obesity, body fat, benign adrenal tumors and the mediating mechanism: a two-step mendelian randomization study
Our study demonstrates that obesity and elevated body fat may serve as risk factors for benign adrenal tumors. Furthermore, we identify the mediating role of total/bioavailable testosterone levels in women, suggesting its potential target for prevention and intervention of benign adrenal tumors in individuals with obesity or high body fat.
Authors
- Dingyang Lv
- Jinshuai Li (ORCID: https://orcid.org/0009-0006-1608-7149)
- Weibing Shuang (ORCID: https://orcid.org/0000-0001-9597-1886)
- Mohan Jia
- Huiyu Zhou (ORCID: https://orcid.org/0000-0003-1634-9840)
- Hongyang Du (ORCID: https://orcid.org/0000-0002-8220-6525)
- Jie Wen (ORCID: https://orcid.org/0000-0002-4956-1875)
- Qiwei Wang (ORCID: https://orcid.org/0009-0003-0401-8486)
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s12885-025-13774-0
- Citations
- 5
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 6.47