Irradiation-responsive PRDM10-DT modulates the angiogenic response in human NSCLC cells in an SP1-dependent manner via the miR-663a/TGF-β1 axis
These results illustrate the proangiogenic function of the PRDM10-DT/miR-663a/TGF-β1 axis and reveal the regulatory role of ROS and SP1 in the upstream response to radiation, with differential ROS production mediating the differential angiogenesis levels after X-ray and C-ion irradiation. Our findings suggest the potential of PRDM10-DT as a nucleic acid biomarker after radiotherapy and that targeting this gene could be a therapeutic strategy to counteract angiogenesis in NSCLC radiotherapy.
Authors
- Guangming Zhou (ORCID: https://orcid.org/0000-0001-5695-2308)
- Hao Huang (ORCID: https://orcid.org/0000-0002-6687-6967)
- Yidan Song (ORCID: https://orcid.org/0009-0006-5433-9837)
- Zi Guo
- Wentao Hu (ORCID: https://orcid.org/0000-0001-8495-4175)
- Wanshi Li (ORCID: https://orcid.org/0009-0003-7977-7575)
- Tom K. Hei (ORCID: https://orcid.org/0000-0003-3553-1007)
- Ying Xu (ORCID: https://orcid.org/0000-0002-9987-2057)
- Miaomiao Zhang (ORCID: https://orcid.org/0000-0002-3577-6170)
- Jing Nie (ORCID: https://orcid.org/0000-0001-5080-6553)
Institutions
- Soochow University (CN)
- Columbia University (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s12967-025-06273-0
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions