Urinary metabolite model to predict the dying process in lung cancer patients
These metabolites identified offer insights into previously undocumented pathways involved in or affected by the dying process. They not only imply cancer's influence on the body but also illustrate the dying process. Given the similar dying trajectory observed in individuals with cancer, our findings likely apply to other cancer types. Prognostic tests, based on the metabolites we identified, could aid clinicians in the early recognition of people who may be dying and thereby influence clinical practice and improve the care of dying patients.
Authors
- Ivayla Roberts (ORCID: https://orcid.org/0000-0003-3525-9787)
- Brendan P. Norman (ORCID: https://orcid.org/0000-0001-9293-4852)
- C Probert (ORCID: https://orcid.org/0000-0003-4550-0239)
- Elinor Chapman (ORCID: https://orcid.org/0000-0002-4398-1705)
- Amara Callistus Nwosu (ORCID: https://orcid.org/0000-0003-0014-3741)
- L. Ranganath (ORCID: https://orcid.org/0000-0002-4205-2269)
- John Ellershaw (ORCID: https://orcid.org/0000-0001-9789-3180)
- J. Baker (ORCID: https://orcid.org/0000-0002-6562-1081)
- Rachael Slater (ORCID: https://orcid.org/0000-0001-9765-6978)
- Mark T. Boyd (ORCID: https://orcid.org/0000-0002-2336-2106)
- Catriona R Mayland (ORCID: https://orcid.org/0000-0002-1440-9953)
- Douglas B. Kell (ORCID: https://orcid.org/0000-0001-5838-7963)
- Andrew Davison (ORCID: https://orcid.org/0000-0001-5501-4475)
- Séamus Coyle (ORCID: https://orcid.org/0000-0002-4761-9703)
- David M. Hughes (ORCID: https://orcid.org/0000-0002-1287-9994)
- Stephen Mason (ORCID: https://orcid.org/0000-0002-4020-6869)
- James A. Gallagher
Institutions
- University of Liverpool (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Novo Nordisk Foundation (DK)
- Clatterbridge Cancer Centre NHS Foundation Trust (GB)
- Marie Curie Hospice (GB)
- Lancaster University (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1038/s43856-025-00764-3
- Citations
- 5
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- North West Cancer Research
- Novo Nordisk Fonden