Improving activity of GenB3 and GenB4 in gentamicin dideoxygenation biosynthesis by semi-rational engineering
Our results not only lay the foundation for the mild and efficient synthesis of C6'-modified AGs analogues but also serve as a reference for synthesizing additional single components in M. echinospora by further enhancing the dideoxygenation process.
Authors
- Qi Ye (ORCID: https://orcid.org/0000-0002-7268-0530)
- Huanzhang Xia (ORCID: https://orcid.org/0000-0003-1114-6833)
- Botong Liu
- Lihua Yang (ORCID: https://orcid.org/0000-0002-4660-9060)
- Jianming Pei (ORCID: https://orcid.org/0000-0001-9932-8206)
- Xianpu Ni (ORCID: https://orcid.org/0000-0002-5666-3271)
- Zhijun Kong
- Shumin Zhang (ORCID: https://orcid.org/0000-0002-9030-8070)
- Tingting Tian
- Xiaotang Chen (ORCID: https://orcid.org/0000-0003-0467-1488)
- Yuan Ji (ORCID: https://orcid.org/0000-0002-2631-9082)
- Hang Zhai
Institutions
- Shenyang Pharmaceutical University (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s12934-025-02678-0
- Citations
- 1
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province
- Scientific Research Fund of Liaoning Provincial Education Department